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Navigation Labs Laboratory for Basic and Translational Cognitive Neuroscience (Dr. Steve Luck) Laboratory for Brain and Language (Tamara Swaab) Affiliated Labs Neurocognitive Development Lab (Dr. Susan Rivera) People_old Lab News Research Areas Participate Links Participate test folder MRI MRI Information for Parents Publications Young adult male carriers of the Fragile X premutation (fXPCs) exhibit genetically modulated impairments in visuospatial tasks controlled for psychomotor speed The effect of the FMR1 gene on motor fiber tracts in males with normal and premulation alleles. Psychiatric features in high-functioning adult brothers with fragile X spectrum disorders. Cortical folding abnormalities in autism revealed by surface-based morphometry. Word comprehension facilitates object individuation in 10- and 11-month-old infants. The neuroanatomy and neuroendocrinology of fragile X syndrome. Functional brain activation during arithmetic processing in females with fragile X syndrome is related to FMR-1 protein expression. Amygdala dysfunction in men with the fragile X premutation. Volumetric brain changes in females with fragile X associated tremor/ataxia syndrome (FXTAS). Molecular and imaging correlates of the fragile X-associated tremor/ataxia syndrome. Developmental changes in mental arithmetic: Evidence for increased functional specialization in the left inferior parietal cortex. Prefrontal cortex involvement in processing incorrect arithmetic equations: Evidence from event-related fMRI. Dissociating prefrontal and parietal cortex activation during arithmetic processing. Functional optimization of arithmetic processing in perfect performers. The drawbridge phenomenon: representational reasoning or perceptual preference? Can young infants add and subtract? Unraveling the mystery of motion perception impairments in autism: Some further considerations. Functional MRI of working memory in pediatric head injury: A longitudinal case study. Early Cognitive Development: Ontogeny and Phylogeny. Not proved: Reply to Wynn. Contrast detection in infants with fragile X syndrome. From genes to brain to behavior: The case of fragile X Syndrome. The fragile X family of disorders: A model for autism and targeted treatments. Neuroanatomical Approaches to the Study of Mathematical Ability and Disability. Development of multimodal numerical processing in infancy. Brief report: Visual processing of faces in individuals with fragile X syndrome: An eye tracking study. A functional and structural study of emotion and face processing in children with autism. Reduced hippocampal activation during recall is associated with elevated FMR1 mRNA and psychiatric symptoms in men with the fragile X premutation. Object permanence and method of disappearance: looking measures further contradict reaching measures. Psychological symptoms correlate with reduced hippocampal volume in fragile X premutation carriers. Abnormal fMRI activation pattern during story listening in Down syndrome. The psychophysics of visual motion and global form processing in autism. Holistic crowding of Mooney faces. A review of fragile X premutation disorders: expanding the psychiatric perspective. Dynamic object representations in infants with and without fragile X syndrome. Radiological findings in FXTAS. In F. Tassone and E. Berry-Kravis (Eds), The Fragile X Tremor Ataxia Syndrome. An fMRI study of the prefrontal activity during the performance of a working memory task in premutation carriers of the fragile X mental retardation 1 gene with and without fragile X-associated tremor/ataxia syndrome (FXTAS). Side effects of minocycline treatment in patients with fragile X syndrome and exploration of outcome measures. Spatial resolution of conscious visual perception in infants. A voxel-based morphometry study of grey matter loss in fragile X-associated tremor/ataxia syndrome. Diffusion tensor imaging in male premutation carriers of the fragile X mental retardation gene. Young adult female fragile X premutation carriers show age- and genetically-modulated cognitive impairments. Time Crawls: The temporal Resolution of infants' visual attention. Neural correlates of coherent and biological motion perception in autism. Enhanced manual and oral motor reaction time in young adult female fragile X premutation carriers. Adult female fragile X premutation carriers exhibit age- and CGG repeat length-related impairments on an attentional-based enumeration task Decreased fragile X mental retardation protein expression underlies amygdala dysfunction in carriers of the fragile X premutation. Investigation of amygdala volume in men with the fragile X premutation. Age-dependent structural connectivity effects in fragile X premutation. Resolution of spatial and temporal visual attention in infants with fragile X syndrome Sertraline may improve language developmental trajectory in young children with fragile X syndrome: A retrospective chart review. Influence of the fragile X mental retardation (FMR1) gene on the brain and working memory in men with normal FMR1 alleles. Male carriers of the FMR1 premutation show altered hippocampal-prefrontal function during memory encoding 267 Cousteau Place Davis, CA 95618 (530) 297-4651 phone (530) 297-4400 fax Quick links University Library MyUCDavis Search the CMB

Center for Mind and Brain > Labs > Neurocognitive Development Lab (Dr. Susan Rivera) > Publications > Investigation of amygdala volume in men with the fragile X premutation. Personal tools Log in D. Selmeczy, K. Koldewyn, J.M. Wang, A. Lee, D. Harvey, D.R. Hessl, F. Tassone, P. Adams, R.J. Hagerman, P.J. Hagerman, and S.M. Rivera (2011) Investigation of amygdala volume in men with the fragile X premutation. Brain Imaging and Behavior 5(4):285-294. Abstract Premutation fragile X carriers have a CGG repeat expansion (55 to 200 repeats) in the promoter region of the fragile X mental retardation 1 (FMR1) gene. Amygdala dysfunction has been observed in premutation symptomatology, and recent research has suggested the amygdala as an area susceptible to the molecular effects of the premutation. The current study utilizes structural magnetic resonance imaging (MRI) to examine the relationship between amygdala volume, CGG expansion size, FMR1 mRNA, and psychological symptoms in male premutation carriers without FXTAS compared with age and IQ matched controls. No significant between group differences in amygdala volume were found. However, a significant negative correlation between amygdala volume and CGG was found in the lower range of CGG repeat expansions, but not in the higher range of CGG repeat expansions. URL http://mindbrain.ucdavis.edu/people/srivera/Selmeczy%20et%20al.%20%20Investigation%20of%20amygdala%20volume%20in%20men%20with%20the%20FXS%20Pre.pdf